ESPE Yearbook of Paediatric Endocrinology

ESPE Yearbook of Paediatric Endocrinology

ISSN 1662-4009 (online)

Published by BioScientifica

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ey0020.3-18 | Advances in Growth, Bone Biology, and Mineral Metabolism | ESPEYB20

3.18. Periosteal stem cells control growth plate stem cells during postnatal skeletal growth

M Tsukasaki , N Komatsu , T Negishi-Koga , NC Huynh , R Muro , Y Ando , Y Seki , A Terashima , W Pluemsakunthai , T Nitta , T Nakamura , T Nakashima , S Ohba , H Akiyama , K Okamoto , R Baron , H Takayanagi

In Brief: The authors use cell tracing approaches in a PRMT5flox/Δ Ctsk-Cre strain to label periosteal stem cells (PSCs) and show that PSCs are not only essential for intramembranous bone formation but also for endochondral bone formation. The study identifies the role of PSC derived indian hedgehog (Ihh) in maintaining growth plate homeostasis and postnatal skeletal growth.Commentary: The skeleton harbors stem cells in three independent ...
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Published by BioScientifica

ESPE Yearbook of Paediatric Endocrinology
ISSN 1662-4009 (Online)
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